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Ethylisopropyl-amiloride: a new and highly potent derivative of amiloride for the inhibition of the Na+/H+ exchange system in various cell types |
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| Authors: | P Vigne C Frelin E J Cragoe M Lazdunski |
| Institution: | Department of Biochemistry, School of Dentistry, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142, Japan |
| Abstract: | Ethylisopropyl-amiloride is 100 times more potent than amiloride for inhibiting the Na+/H+ exchanger of 3T3 fibroblasts, chick skeletal muscle cells and chick cardiac cells. Half-maximum effects, measured at 3 mM external Na+ are observed at 20-100 nM and 5 microM for ethylisopropyl-amiloride and amiloride respectively. As previously observed for amiloride, the effect of ethylisopropyl-amiloride is antagonized by external Na+ ions. |
| Keywords: | M1 a mouse myeloid leukemia cell line HL-60 a human myeloid leukemia cell line U937 a human histiocytic monoblast-like lymphoma cell line TPA NBT nitro-blue tetrazolium |
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