Physico-chemical characterization of meglumine antimoniate |
| |
| Authors: | Cynthia Demicheli Tatiana L. de Figueiredo Sandra Carvalho Ruben D. Sinesterra Júlio C.D Lopes Frédéric Frézard |
| |
| Affiliation: | (1) Departamento de Química, Universidade Federal de Minas Gerais, Belo Horizonte, 31270-901 Minas Gerais, Brasil;(2) Departamento de Biofísica e Fisiologia, Universidade Federal de Minas Gerais, Belo Horizonte, 31270-901 Minas Gerais, Brasil |
| |
| Abstract: | The leishmanicidal drug, meglumine antimoniate (MA), has been synthesized by the reaction of antimony oxyhydrated and N-methyl glucamine. Infrared and solid state NMR 13C analysis of MA and the ligand strongly suggests that antimony binds to N-methyl glucamine through the oxygen of C-3 carbon. Potentiometric titration indicated that, between pH 4.5 and 7.5, MA exists in the zwitterionic form |
| |
| Keywords: | meglumine antimoniate structure leishmaniasis |
| 本文献已被 SpringerLink 等数据库收录！ |
|
