Chromosomal inversion discovered in C3H/HeJ mice |
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Authors: | Akeson Ellen C Donahue Leah Rae Beamer Wesley G Shultz Kathy L Ackert-Bicknell Cheryl Rosen Clifford J Corrigan Jennifer Davisson Muriel T |
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Affiliation: | The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA. |
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Abstract: | Mice of the inbred mouse strain C3H/HeJ have been shown to be homozygous for a chromosomal inversion on Chromosome (Chr) 6. The inversion encompasses about 20% of the chromosome from approximately 73 Mb to approximately 116 Mb. The importance of this finding is that linkage crosses using C3H/HeJ will show no recombination in this region of Chr 6. The inversion has no apparent effect on the phenotype of C3H/HeJ mice and its presence should not affect biological studies; however, use of C3H/HeJ mice for genetic analysis of Chr 6 should be avoided or the results interpreted with the inversion in mind. The inversion has been named In(6)1J (inversion Chr 6, Jackson 1). |
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