A thyroid hormone-vasopressin interaction promotes survival and maturation of hippocampal neurons dissociated postnatally |
| |
| Authors: | Jean Clos Jacqueline Gabrion |
| |
| Affiliation: | (1) Unité de Neurobiologie Endocrinologieque, CNRS. URA 1197, Université de Montpellier II, 34060 Montpellier, France;(2) Laboratoire de Physiologie comparée, URA 1197 du CNRS, Université des Sciences et Techniques du Languedoc, Place Eugéne Bataillon, F 34060 Montpellier |
| |
| Abstract: | Hippocampal cells dissociated from 5-day-old rat pups were grown in a suitable chemically defined basal medium, supplemented or not with 3,3 ,5-triiodo-l-thyronine (T3), [Arg8]-vasopressin (AVP), or both, at different concentrations. Four days after plating, neuron-like cells began to degenerate drastically in the basal medium. Although AVP alone had no effect, T3, and to a greater extent T3 and AVP together, prevented their death. Moreover, T3, and AVP also acted synergically in promoting the maturation of surviving cells, especially AchE-positive neurons, either directly or through glial cells.Special issue dedicated to Dr. Paola S. Timiras |
| |
| Keywords: | T3 AVP hippocampal neurons survival maturation |
| 本文献已被 SpringerLink 等数据库收录！ |
|
