Every single cell clones from cancer cell lines growing tumors <Emphasis Type="Italic">in vivo</Emphasis> may not invalidate the cancer stem cell concept |
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Authors: | Fengzhi Li |
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Institution: | (1) Departments of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA |
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Abstract: | We present the result of our research on the tumorigenic ability of single cell clones isolated from an aggressive murine
breast cancer cell line in a matched allografting mouse model. Tumor formation is basically dependent on the cell numbers
injected per location. We argue that in vivo tumor formation from single cell clones, isolated in vivo from cancer cell lines, may not provide conclusive evidence to disprove the cancer stem cell (CSC) theory without additional
data. |
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Keywords: | allografting cancer cell line cancer stem cell single cell clone tumorigenic |
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