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Vanadium complexes with 2-pyridineformamide thiosemicarbazones: In vitro studies of insulin-like activity |
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| Authors: | Isolda C Mendes Adaliene VM Ferreira Heloisa Beraldo |
| Institution: | a Departamento de Química, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, Brazil b Departamento de Fisiologia e Biofísica, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, Brazil c Instituto de Física, Universidade de São Paulo, São Carlos, Brazil |
| Abstract: | Reaction of VOCl2 with 2-pyridineformamide thiosemicarbazone (H2Am4DH) and its N(4)-methyl (H2Am4Me), N(4)-ethyl (H2Am4Et) and N(4)-phenyl (H2Am4Ph) derivatives in ethanol gave as products VO(H2Am4DH)Cl2] (1), VO(H2Am4Me)Cl2] · 1/2HCl (2), VO(H2Am4Et)Cl2] · HCl (3) and VO(2Am4Ph)Cl] (4). Upon the dissolution of 1-4 in water, oxidation immediately occurs with the formation of VO2(2Am4DH)] (5), VO2(2Am4Me)] (6), VO2(2Am4Et)] (7) and VO2(2Am4Ph)] (8). The crystal and molecular structures of 5 and 6 were determined. Complexes 5-8 inhibited glycerol release in a similar way to that observed with insulin but showed a low enhancing effect on glucose uptake by rat adipocytes. |
| Keywords: | 2-Pyridineformamide thiosemicarbazones Vanadium Insulin-like |
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