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Bis(pyrazolyl) palladium(II), platinum(II) and gold(III) complexes: Syntheses, molecular structures and substitution reactions with l-cysteine |
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| Authors: | Frankline K. Keter Olayinka A. Oyetunji James Darkwa |
| Affiliation: | a Department of Chemistry, University of Johannesburg, P.O. Box 524 Auckland Park 2006, South Africa b Department of Chemistry, University of Botswana, Private Bag UB 00704, Gaborone, Botswana c Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, WI 53706, USA |
| Abstract: | A series of pyrazolyl palladium(II), platinum(II) and gold(III) complexes, [PdCl2(3,5-R2bpza)] {R = H (1), R = Me (2), bpza = bis-pyrazolyl acetic acid}, [PtCl2(3,5-R2bpza)] {R = H (3a), R = Me (4)}, [AuCl2(3,5-R2bpza)]Cl {R = H (5a), R = Me (6a)} and [PdCl2(3,5-R2bpzate)] {R = Me (7)} have been synthesised and structurally characterised. Single crystal X-ray crystallography showed that the pyrazolyl ligands exhibit N^N-coordination with the metals. Anticancer activities of six complexes 1-6a were investigated against CHO cells and were found to have low activities. Substitution reactions of selected complexes 1, 2, 3a and 5a with l-cysteine show that the low anticancer activities compounds and that the rate of substitution with sulfur-containing compounds is not the cause of the low anticancer activities. |
| Keywords: | Bis(pyrazolyl)acetic acid compounds Cytotoxicity Pseudo first-order Substitution smallcaps" >l-cysteine |
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