Facile one-pot mono-dealkylation of H-phosphonate esters in high yield |
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| Authors: | David E. Bryant Colin Kilner Terence P. Kee |
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| Affiliation: | School of Chemistry, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, UK |
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| Abstract: | The readily available dialkyl H-phosphonates (RO)2P(O)H, where R = Me, Et, iPr, nBu and Bn can be mono-dealkylated by heating at reflux in excess tert-butylamine. Where R = Me or Bn then crystals of [(CH3)3CNH3]+ [ROP(O)HO]− form in the reaction vessel on overnight standing. |
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| Keywords: | Dealkylation Phosphonate esters Amines |
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