Demonstration of beta-casomorphin immunoreactive materials in in vitro digests of bovine milk and in small intestine contents after bovine milk ingestion in adult humans |
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Authors: | J Svedberg J de Haas G Leimenstoll F Paul H Teschemacher |
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Institution: | 1. Rudolf Buchheim-Institut für Pharmakologie der Justus Liebig-Universität Gießen, 6300 Gießen, FRG;2. I. Medizinische Klinik der Universität Kiel, 2300 Kiel, FRG;3. Med. Klinik II, Klinikum Ingolstadt, 8070 Ingolstadt, FRG |
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Abstract: | Healthy young volunteers ingested one liter of cows' milk; then the contents of the small intestine were aspirated through an intestinal tube at various times and assayed for the presence of bovine beta-casomorphin immunoreactive materials. Considerable amounts of beta-casomorphin-7, but no beta-casomorphin-5 and only small amounts of beta-casomorphin-4 or -6 immunoreactive materials were found. Chromatographical characterization showed that most of the beta-casomorphin-7 immunoreactive material was not identical with beta-casomorphin-7, whereas the major part of the beta-casomorphin-4 or -6 immunoreactive materials might be identical with their corresponding beta-casomorphins. Analogous results were obtained for in vitro digestion of bovine milk which had been designed as a rough imitation of the gastrointestinal digestion process. A regulatory influence of beta-casomorphins as "food hormones" on intestinal functions is suggested. |
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Keywords: | β-Casomorphins in the intestine Opioid peptides β-Casomorphin immunoreactivity in milk digests Biological significance of β-casomorphins Food peptides β-Casein Cows' milk Milk digestion |
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