植物非组蛋白赖氨酸乙酰化修饰的蛋白质组学研究进展

蛋白质赖氨酸乙酰化是植物中普遍存在的重要蛋白质翻译后修饰过程。过去的研究主要集中在染色体组蛋白的乙酰化修饰及其调控机制。目前,随着定量乙酰化蛋白质组学技术的发展,大量非组蛋白赖氨酸乙酰化修饰被发现,其在植物中存在的普遍性及其生理功能的重要性也随之凸显。非组蛋白赖氨酸乙酰化修饰在植物不同组织、器官和细胞器中大量存在,广泛参与植物生长发育的各种代谢过程的调控,并在植物应答和适应逆境胁迫中发挥作用。综述了近年来植物非组蛋白赖氨酸乙酰化修饰的蛋白质组学研究进展,阐明乙酰化修饰在植物不同组织和亚细胞中的分布特征以及在植物生长发育和逆境胁迫响应中的作用,并阐述乙酰化修饰与其他蛋白质翻译后修饰的交互作用,最后对未来的研究进行展望和讨论。

Research Progress of Plant Lysine Acetylproteome Modified in Nonhistone Protein

Protein lysine acetylation is an important and common protein post-translational modification in plants.The prior researches had focused on acetylation modification of histones in chromosomes and their regulatory mechanisms.Recently,with the development of quantitative acetylproteome,a large number of non-histone proteins with lysine acetylation modification have been discovered,and the universality of its existence in biology and the importance of its function have also been highlighted.Non-histone protein lysine acetylation modification is abundant in different tissues,organs and organelles of plants.It is widely involved in various metabolic processes during the growth and development,and also plays important roles in responses and adaptation to stresses.In this review,we summarize the recent acetylproteome researches in non-histone lysine acetylation modification in plants.Then we describe the distribution characteristics of identified acetylated proteins in different tissues and subcellular organelles.Further we reveal the functions of acetylation modification in growth,development and responses to stresses,crosstalk between lysine acetylation and other protein post-translational modifications.Finally,we prospect and discuss the future research directions.