基于代谢组学的植物多酚及其肠道健康效应研究进展

综述了植物多酚的分类和来源、在代谢组学技术的驱动下,新型多酚物质的鉴定、控制植物多酚合成途径的关键因子以及多酚的功能特性的研究进展,阐述了植物多酚在肠道中的代谢以及其作为“益生元”调节肠道微生态并影响机体健康的重要功能。目前的研究表明不同植物多酚在调节肠道微生态方面存在差异,多数有促进肠道有益菌作用,并通过与肠道微生物“互作”发挥促进健康效应。总之,植物多酚作为“益生元”影响人体健康可能离不开肠道微生物的介导。各个植物多酚的益生功能也需要进一步阐析,在此过程中需要考虑宿主,膳食等混杂因素的综合影响,且需要拓展临床应用方面的研究。

Progress Based on Metabolomics:Plant Polyphenols and Their Gut Health Benefit

This article provides a general overview of the classification and the sources of plant polyphenols,as well as the recent studies using metabolomics technology in the realms of 1)the identification of novel polyphenols,2)the key factors in polyphenols synthesis pathways and,3)the biological function of plant polyphenols.The metabolism of plant polyphenols in the gut and their functions as prebiotics in regulation of gut microbiota are also discussed.The current studies show that different plant polyphenols play varied roles in regulating gut microbiota,but most of them tend to promote beneficial bacteria,and the health benefits of polyphenols on gut microbiota are in function via interaction with the host.In a word,plant polyphenols as“probiotics”affecting human health relies on the mediation of intestinal microbes.The probiotic function of individual plant polyphenol deserves further investigation,including the factors of host,diet and other confounding factors,as well as expanding studies on clinical trials.