Effects of antibiotics on the life cycle ofNeurospora crassa |
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Authors: | V Betina D Janstová J Spisiaková |
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Institution: | (1) Department of Technical Microbiology and Biochemistry, Faculty of Chemistry, Slovak Polytechnical University, 880 37 Bratislava |
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Abstract: | Some antibiotics and synthetic inhibitors affect, in several ways, the life cycle ofNeurospora crassa (germination of conidia → myceliar growth → formation of conidia). Bikaverin, cyanein, scopathrioin and phenethyl alcohol
retard the germination of conidia, without inhibiting it completely. 5-Fluorouracil, ramihyphin A and zygosporin A (cytoohalasin
D) do not inhibit the germination. Bikaverin brings about a thickening of the hyphae of growing mycelium. Ramihyphin A, cyanein,
scopathricin and zygosporin A stimulate the ramification of hyphae while 5-fluorouracil and phenethyl alcohol do not affect
the myceliar morphology apart from their inhibitory effect on growth. Actinomycin D, 5-fluorouracil, cycloheximide, ramihyphin
A and partially also sodium iodoacetate inhibit to a different degree the photoinduced formation of conidia. The inhibition
by 5-fluorouracil is very conspicuous when the agent is present during the photoinduction but considerably weaker when it
is applied 2 h after the photoinduction. |
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