Electrophoretically homogeneous myeloma light chain mRNA and its translation in vitro |
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Authors: | S Tonegawa I Baldi |
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Affiliation: | Basel Institute for Immunology, 487 Grenzacherstrasse, CH-4058 Basel, Switzerland. |
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Abstract: | mRNA coding for the light chain of a myeloma protein has been purified to give one band in acrylamide gel electrophoresis. This pure RNA (S~13.5) could be translated into the light chain in a heterologous cell-free translation system. The light chain synthesized is apparently slightly larger than the light chain secreted by the tumor. |
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