| FOLFOX4和XELOX两周方案用于进展期胃癌新辅助化疗的随机对照研究 |
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| 引用本文： | 崔文峰,杨俊省,张学彬,寇晨光,赵磊,林惠忠. FOLFOX4和XELOX两周方案用于进展期胃癌新辅助化疗的随机对照研究[J]. 现代生物医学进展, 2010, 10(2) |
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| 作者姓名： | 崔文峰 杨俊省 张学彬 寇晨光 赵磊 林惠忠 |
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| 作者单位： | 1. 山东省青岛大学,山东,青岛,266071
2. 青岛市立医院,山东,青岛,266071 |
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| 摘 要： | 目的:观察FOLFOX4和XELOX新辅助化疗方案治疗局部进展期胃癌的疗效和毒副作用。方法:68例初治确诊为局部进展期胃癌的患者,随机分为两组,每组各34例,分别采用XELOX和FOLFOX4化疗方案行术前两个疗程的化疗治疗。结果:XELOX组总有效率为47.06%,FOLFOX4组总有效率为41.08%,两组间无显著性差异。不良反应方面,FOLFOX4组恶心、呕吐,白细胞减少和口腔黏膜炎发生率较高,而XELOX组手足综合症发生率较高。结论:XELOX方案作为胃癌新辅助化疗方案,疗效与FOLFOX4方案相似,但XELOX方案副作用较轻且均可控制,化疗时间短,对机体损伤小,易于接受,值得在临床工作中进一步研究和推广。
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| 关 键 词： | 进展期胃癌 新辅助化疗 希罗达 奥沙利铂 |
FOLFOX4 and XELOX Program as Neoadjuvant Chemotherapy Biweekly for Advanced Gastric Cancer: A Randomized Controlled Study |
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| CUI Wen-feng,YANG Jun-sheng,ZHANG Xue-bin,KOU Chen-guang,ZHAO Lei,LIN Hui-zhong. FOLFOX4 and XELOX Program as Neoadjuvant Chemotherapy Biweekly for Advanced Gastric Cancer: A Randomized Controlled Study[J]. Progress in Modern Biomedicine, 2010, 10(2) |
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| Authors: | CUI Wen-feng YANG Jun-sheng ZHANG Xue-bin KOU Chen-guang ZHAO Lei LIN Hui-zhong |
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| Affiliation: | CUI Wen-feng1,YANG Jun-sheng1,ZHANG Xue-bin1,KOU Chen-guang1,ZHAO Lei1,LIN Hui-zhong2(1Qingdao University Shangdong Qingdao 266071,2 Qingdao Municipal Hospital,Qingdao 266071) |
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| Abstract: | Objective:To investigate the treatment efficacy and side effects of FOLFOX4 and XELOX as neoadjuvant chemotherapy in locally advanced gastric cancer. Methods:68 cases diagnosed to be locally advanced gastric cancer were randomly divided into two groups,34 cases of patients in each group. The chemotherapy treatment of XELOX and FOLFOX4 were used before the operations for two courses of treatment. Results:The total effective rate in Group XELOX is 47.06%,while it is 41.08% in Group FOLFOX4. The incidence of n... |
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| Keywords: | advanced gastric cancer neo-adjuvant chemotherapy Xeloda Oxaliplatin |
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