A field-study of inducible molecular defenses,ultraviolet radiation,and melanomagenesis in natural <Emphasis Type="Italic">Xiphophorus</Emphasis> hybrids |
| |
Authors: | Seth W Coleman Zachary W Culumber Ashley Meaders Jennifer Henson Gil G Rosenthal |
| |
Institution: | 1.Department of Biology,Texas A & M University,College Station,USA;2.Centro de Investigaciones Científicas de las Huastecas “Aguazarca”,Hidalgo,Mexico;3.Biology Department,Gonzaga University,Spokane,USA |
| |
Abstract: | Ultraviolet radiation—the primary natural pollutant affecting melanomagenesis—may represent a widespread ecological stressor
for many fishes, and yet the relationship between UV-exposure and stress has not been investigated in natural fish populations.
Recent lab-based studies have sought to characterize the relationship between tumorigenesis and the induction of molecular
defenses, such as heat shock proteins. Here we show that ultraviolet radiation and heat shock protein gene expression explain
a significant amount of the variation in hyper-melanization—the phenotypic precursor to melanoma—in wild hybrids of Xiphophorus, laboratory models in cancer research. Our results suggest exposure to UV radiation causes stress which induces molecular
defense mechanisms, which in turn may facilitate tumorigenesis in natural fish populations. Studies of laboratory-based model
organisms in natural settings, like this one, may provide important insights into ecological and evolutionary relationships
obscured in controlled laboratory environments. We hope that ours is only the first of many studies to investigate the such
relationships between environmental stress, stress-induced molecular defenses, and cancer in fishes. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|