Iron-responsive regulation of biofilm formation in staphylococcus aureus involves fur-dependent and fur-independent mechanisms |
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Authors: | Johnson Miranda Cockayne Alan Williams Peter H Morrissey Julie A |
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Institution: | Department of Genetics, University of Leicester, UK. jam26@le.ac.uk. |
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Abstract: | We have shown that Staphylococcus aureus biofilm production is induced in iron-restricted conditions and is repressed by iron via a Fur-independent mechanism, while Fur has both positive and negative regulatory roles in low iron. Furthermore, there is no significant increase in polymeric N-acetylglucosamine polysaccharide expression to account for induction of biofilms in low iron. |
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