Suramin induces lysosomal storage disorder in HT29-D4 cells during a mechanism of polarized endocytosis] |
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| Authors: | S Baghdiguian J A Boudier B Verrier J P Zappitelli J Fantini |
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| Affiliation: | Lab. d'Histologie, Fac. de Médecine Secteur Nord, Marseille. |
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| Abstract: | During the course of suramin-induced differentiation, a marked lysosomal storage disorder is observed in HT29-D4. This impairment could account for the toxic side effects of the drug during clinical trials in humans. It is shown that the perturbation is caused by a process of endocytosis of suramin-serum albumin complexes by the apical membrane of differentiated HT29-D4 cells. |
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