Delayed-type hypersensitivity to myelin basic proteins in mice susceptible to allergic encephalomyelitis |
| |
| Authors: | D Scott Linthicum George A Hashim |
| |
| Institution: | (1) Department of Pathology and Neurology, University of Texas Health Science Center at Houston, P. O. Box 20708, 77025 Houston, Texas;(2) Department of Surgery and Microbiology, St. Like's-Roosevelt Hospital Center and Columbia University, New York, New York |
| |
| Abstract: | The delayed-type hypersensitivity (DTH) response in mice immunized with autologous spinal cord homogenate or purified myelin basic protein (MBP) was measured by the125I-UdR uptake ear assay. Mice were tested for DTH responses with MBP preparations from different species and with synthetic peptides. The 114–122 and 68–84 peptide regions appear to be major determinants for inducing and eliciting DTH in the mice which are susceptible to allergic encephalomyelitis.Special Issue dedicated to Dr. Elizabeth Robez-Einstein.This investigation was supported by Grant No. 1256-B-3 and RG 1197-B7 from the National Multiple Sclerosis Society, N.Y. and a grant from The Margaret T. Biddle Foundation. D.S.L. is a Scholar of the Leukemia Society of America, Inc. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
