Cytotoxic effector cell function in organized gut-associated lymphoid tissue (GALT). |
| |
Authors: | D L Nelson B M Bundy R M Blaese W Strober |
| |
Institution: | Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014 USA |
| |
Abstract: | Lymphocytes from the organized gut-associated lymphoid tissues (GALT) of adult guinea pigs were examined for surface markers characteristic of T and B lymphocytes and for their capacity to function as effector cells in mitogen-induced cellular cytotoxicity (MICC) and antibody-dependent cellular cytotoxicity (ADCC) reactions. GALT lymphocytes formed rosettes with rabbit erythrocytes, a T-cell marker, and underwent proliferative responses in vitro in the presence of phytohemagglutinin (PHA), concanavalin A (Con A), and pokeweed mitogen (PWM). GALT lymphocytes were cytotoxic in vitro for erythrocyte and DBA mastocytoma targets in the presence of PHA. A population of GALT lymphocytes bound aggregated γ-globulin; however, they functioned poorly in ADCC reactions. Thus, organized GALT in the guinea pig contains lymphocytes capable of functioning in T-cell-dependent MICC reactions but either lacks the effector cell population which mediates ADCC or contains an effector cell which functions poorly in ADCC. |
| |
Keywords: | Address for reprints: Bldg 10 Rm 4N114 National Institutes of Health Bethesda Md 20014 |
本文献已被 ScienceDirect 等数据库收录! |
|