Effect of the TP5 analogue of thymopoietin on the rejection of male skin by aged and thymectomized female mice |
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| Authors: | Ellen H Goldberg Gideon Goldstein Edward A Boyse Margrit P Scheid |
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| Affiliation: | (1) Department of Microbiology, University of New Mexico School of Medicine, 87131 Albuquerque, New Mexico;(2) Ortho Pharmaceutical Corporation, 08869 Raritan, New Jersey;(3) Memorial Sloan-Kettering Cancer Center, 10021 New York, New York |
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| Abstract: | Although young adult C3H/HeJ (OH) females do not reject C3H male skin grafts, OH females older than 1 year commonly do so, as also do many thymectomized, young adult C3H females. Therapy With TP5, a synthetic pentapeptide analogue of thymopoietin which has biological properties of the parent molecule, substantially reduced the capacity of aged OH females and of thymectomized, young OH females to reject OH male skin. |
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