ICI 182,780 has agonistic effects and synergizes with estradiol-17 beta in fish liver, but not in testis |
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| Authors: | Patrícia IS Pinto Pratap B Singh João B Condeça Helena R Teodósio Deborah M Power Adelino VM Canário |
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| Affiliation: | 1. Centro de Ciências do Mar, CIMAR-Laboratório Associado, University of Algarve, Faro, Portugal
2. Departmentof Zoology, T.D. College, 222002, Jaunpur, India
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| Abstract: | Background ICI 182,780 (ICI) belongs to a new class of antiestrogens developed to be pure estrogen antagonists and, in addition to its therapeutic use, it has been used to knock-out estrogen and estrogen receptor (ER) actions in several mammalian species. In the present study, the effects and mechanism of action of ICI were investigated in the teleost fish, sea bream (Sparus auratus). |
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