Novel association of ABO histo-blood group antigen with soluble ICAM-1: results of a genome-wide association study of 6,578 women |
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Authors: | Paré Guillaume Chasman Daniel I Kellogg Mark Zee Robert Y L Rifai Nader Badola Sunita Miletich Joseph P Ridker Paul M |
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Affiliation: | Guillaume Paré, Daniel I. Chasman, Mark Kellogg, Robert Y. L. Zee, Nader Rifai, Sunita Badola, Joseph P. Miletich, and Paul M. Ridker |
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Abstract: | While circulating levels of soluble Intercellular Adhesion Molecule 1 (sICAM-1) have been associated with diverse conditions including myocardial infarction, stroke, malaria, and diabetes, comprehensive analysis of the common genetic determinants of sICAM-1 is not available. In a genome-wide association study conducted among 6,578 participants in the Women's Genome Health Study, we find that three SNPs at the ICAM1 (19p13.2) locus (rs1799969, rs5498 and rs281437) are non-redundantly associated with plasma sICAM-1 concentrations at a genome-wide significance level (P<5×10−8), thus extending prior results from linkage and candidate gene studies. We also find that a single SNP (rs507666, P=5.1×10−29) at the ABO (9q34.2) locus is highly correlated with sICAM-1 concentrations. The novel association at the ABO locus provides evidence for a previously unknown regulatory role of histo-blood group antigens in inflammatory adhesion processes. |
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