A dominant mutation (SAD) bypassing the requirement for the a mating type locus in yeast sporulation |
| |
Authors: | Yona Kassir and Ira Herskowitz |
| |
Institution: | (1) Department of Genetics, Hebrew University, Jerusalem, Israel;(2) Department of Biology, University of Oregon, Eugene, Oregon, USA;(3) Institute of Molecular Biology, University of Oregon, Eugene, Oregon, USA |
| |
Abstract: | Summary
SAD (suppressor of a deficiencies) is a mutation that allows -mater diploids such as / or a1-/ strains to sporulate. This mutation is unstable and reverts to wildtype (sad
+) even in strains homozygous for SAD. SAD is dominant to sad
+: / and a1-/ sad
1/SAD diploids are sporulation-proficient. SAD is located on chromosome III, 40 cM distal to the mating type locus, between THR4 and HMR
a. The ability of SAD to support sporulation requires the presence of an mating type locus with an active 2 function. Possible models for the action of SAD are (1) SAD bypasses the need for a1 function in sporulation, and (2) SAD provides a1 function to MAT
a1- mutants by supplying a1 function itself, for example, by allowing expression of a silent copy of MAT
a. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|