Antigenic changes of a murine lymphoma by in vivo treatment with triazene derivatives |
| |
| Authors: | M C Fioretti B Nardelli R Bianchi C Nisi G Sava |
| |
| Institution: | (1) Institute of Pharmacology, University of Perugia, Via del Giochetto, 06100 Perugia;(2) Institute of Medicinal Chemistry, University of Trieste, Via Valerio, 34100 Trieste;(3) Institute of Pharmacology, University of Trieste, Via Valerio, 34100 Trieste, Italy |
| |
| Abstract: | Summary Five aryltriazenes were studied for efficacy in mediating immunogenic changes of tumor cells by in vivo treatment of lymphoma-bearing mice. It was found that four analog compounds produced increase in cell immunogenicity similar to that described for 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide (DTIC), one of the five being by contrast completely inactive. Moreover, the use of a drug-resistant lymphoma illustrates that cytotoxic activity is not mandatory for the appearance of the immunogenic changes.The results show that a drug-mediated increase of tumor immunogenicity (DMITI) can be induced by triazene derivatives not containing the imidazole moiety. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
