| 中心体异常和肿瘤 |
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| 引用本文： | 金顺钱,吴旻,詹启敏.中心体异常和肿瘤[J].生物化学与生物物理进展,2003,30(4):527-532. |
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| 作者姓名： | 金顺钱 吴旻 詹启敏 |
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| 作者单位： | 中国医学科学院,中国协和医科大学,肿瘤医院,肿瘤研究所,分子肿瘤学国家重点实验室,北京,100021 |
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| 摘 要： | 中心体是紧靠细胞核的小体积细胞器，由中心粒和中心粒外周基质(PCM)组成.中心体的蛋白质组成、形态、大小和位置随细胞周期不断发生变化.中心体复制过程与细胞核内其他事件相耦合，并与DNA复制一样，以半保留方式复制.现已发现了许多中心体蛋白及与中心体复制相关的蛋白激酶，调控着中心体复制的各个步骤.中心体复制还受p53,Rb,p21,Gadd45和Brca1/2等多个负性基因调节，中心体异常与基因组不稳定性存在相关性，并有可能与肿瘤发生过程相关.
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| 关 键 词： | 中心体，基因组稳定性，肿瘤发生 |
| 收稿时间： | 2002/12/18 0:00:00 |
| 修稿时间： | 2002年12月18 |
Centrosome Abnormality and Carcinogenesis |
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| JIN Shun-Qian,WU Min and ZHAN Qi-Min.Centrosome Abnormality and Carcinogenesis[J].Progress In Biochemistry and Biophysics,2003,30(4):527-532. |
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| Authors: | JIN Shun-Qian WU Min and ZHAN Qi-Min |
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| Institution: | National Laboratory of Molecular Oncology, Cancer Institute(Hospital), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China;National Laboratory of Molecular Oncology, Cancer Institute(Hospital), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China;National Laboratory of Molecular Oncology, Cancer Institute(Hospital), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China |
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| Abstract: | Centrosome is a tiny organelle which consists of two barrel-shaped centrioles surrounded by a fibrous meshwork termed as the pericentriolar material(PCM). The composition, morphology, size and position of the centrosome in a cell changes continually with cell cycle progression. Duplication of the centrosome is semiconservative and is coordinated with other cell cycle events, including DNA synthesis. Many centrosome-related proteins and kinases have been found to regulate different steps of centrosome duplication. Many growth-suppression genes such as p53, Rb, p21, Gadd45 and Brca1/2 are also involved in control of the duplication process. Centrosome abnormalities are associated with genomic instability and may play important roles in development of human cancers. |
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| Keywords: | centrosome genomic Stability carcinogenesis |
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