Trace element balance is changed in infected organs during acute <Emphasis Type="Italic">Chlamydophila pneumoniae</Emphasis> infection in mice |
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Authors: | Marie Edvinsson Peter Frisk Ylva Molin Eva Hjelm Nils-Gunnar Ilbäck |
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Institution: | (1) Department of Medical Sciences, Infectious Diseases, Uppsala University Hospital, Uppsala, 75185, Sweden;(2) Research in Metal Biology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden;(3) Department of Medical Sciences, Clinical bacteriology, Uppsala University Hospital, Uppsala, Sweden;(4) Toxicology Division, National Food Administration, Uppsala, Sweden |
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Abstract: | Most infectious diseases are accompanied by changed levels of several trace elements in the blood. However, sequential changes
in trace elements in tissues harbouring bacterial infections have not been studied. In the present study the respiratory pathogen
Chlamydophila
pneumoniae (C. pneumoniae), adapted to C57BL/6J mice, was used to study whether the balance of trace elements is changed in infected organs. Bacteria
were quantitatively measured by real-time PCR in the blood, lungs, liver, aorta, and heart on days 2, 5, and 8 of the infection.
Concentrations of 13 trace elements were measured in the liver, heart, and serum by inductively coupled plasma mass-spectrometry
(ICP-MS). Infected mice developed expected clinical signs of disease and bacteria were found in lungs, liver, and heart on
all days. The number of bacteria peaked on day 2 in the heart and on day 5 in the liver. The copper/zinc (Cu/Zn) ratio in
serum increased as a response to the infection. Cu increased in the liver but did not change in the heart. Iron (Fe) in serum
decreased progressively, whereas in the heart it tended to increase, and in the liver it progressively increased. C. pneumoniae may thus cause a changed trace element balance in target tissues of infection that may be pivotal for bacterial growth. |
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Keywords: | Bacterial infection Heart Liver Serum Trace elements |
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