Life without kinase: cyclin E promotes DNA replication licensing and beyond |
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| Authors: | Zhang Hui |
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| Affiliation: | Department of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA. hui.zhang@yale.edu |
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| Abstract: | In a recent issue of Molecular Cell, Sicinski and colleagues report the surprising discovery that cyclin E promotes replication licensing and transformation independently of CDKs, resolving inconsistencies of inactivating cyclin E and CDK2 in the mouse and cells. |
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