A Model for Short- and Long-range Interactions of Migrating Tumour Cell |
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Authors: | M Aubert M Badoual B Grammaticos |
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Institution: | IMNC, Université Paris VII-Paris XI, CNRS, UMR 8165, Bat. 104, 91406, Orsay, France. aubert@imnc.in2p3.fr |
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Abstract: | We examine the consequences of long-range effects on tumour cell migration. Our starting point are previous results of ours
where we have shown that the migration patterns of glioma cells are best interpreted if one assumes attractive interactions
between cells. Here we complement the cellular automaton model previously introduced by the assumption of the existence of
a chemorepellent produced by the main bulk of large spheroids (in the hypoxic/necrotic areas). Visible effects due to the
presence of such a substance can be found in the density profiles of cells migrating out of a single spheroid as well as in
the angular distribution of cells coming from two close-lying spheroids. These effects depend crucially on the diffusion speed
of the chemorepellent. A comparison of the simulation results to experimental data of Werbowetski et al. allows to draw (tentative)
conclusions on the existence of a chemorepellent and its properties. |
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