Identification of intra-group,inter-individual,and gene-specific variances in mRNA expression profiles in the rheumatoid arthritis synovial membrane |
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Authors: | René Huber Christian Hummert Ulrike Gausmann Dirk Pohlers Dirk Koczan Reinhard Guthke Raimund W Kinne |
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Affiliation: | Department of Orthopedics, Experimental Rheumatology Unit, University Hospital Jena, Waldkrankenhaus Rudolf Elle, Eisenberg, Germany. |
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Abstract: | Introduction Rheumatoid arthritis (RA) is a chronic inflammatory and destructive joint disease characterized by overexpression of pro-inflammatory/pro-destructive genes and other activating genes (for example, proto-oncogenes) in the synovial membrane (SM). The gene expression in disease is often characterized by significant inter-individual variances via specific synchronization/desynchronization of gene expression. To elucidate the contribution of the variance to the pathogenesis of disease, expression variances were tested in SM samples of RA patients, osteoarthritis (OA) patients, and normal controls (NCs). |
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