Crystal structure of human IPS-1/MAVS/VISA/Cardif caspase activation recruitment domain |
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Authors: | Jane A Potter Richard E Randall Garry L Taylor |
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Institution: | (1) Centre for Biomolecular Sciences, University of St Andrews, St Andrews, Fife, KY16 9ST, UK |
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Abstract: | Background IPS-1/MAVS/VISA/Cardif is an adaptor protein that plays a crucial role in the induction of interferons in response to viral
infection. In the initial stage of the intracellular antiviral response two RNA helicases, retinoic acid inducible gene-I
(RIG-I) and melanoma differentiation-association gene 5 (MDA5), are independently able to bind viral RNA in the cytoplasm.
The 62 kDa protein IPS-1/MAVS/VISA/Cardif contains an N-terminal caspase activation and recruitment (CARD) domain that associates
with the CARD regions of RIG-I and MDA5, ultimately leading to the induction of type I interferons. As a first step towards
understanding the molecular basis of this important adaptor protein we have undertaken structural studies of the IPS-1 MAVS/VISA/Cardif
CARD region. |
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Keywords: | |
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