Altered cellular infiltration and cytokine levels during early <Emphasis Type="Italic">Mycobacterium tuberculosis</Emphasis><Emphasis Type="Italic">sigC</Emphasis> mutant infection are associated with late-stage disease attenuation and milder immunopathology in mice |
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| Authors: | Khairul-Bariah Abdul-Majid Lan H Ly Paul J Converse Deborah E Geiman David N McMurray William R Bishai |
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| Institution: | (1) Center for Tuberculosis Research, Division of Infectious Diseases, Department of Medicine, Johns Hopkins University, 21231-1001 Baltimore, MD, USA;(2) Department of Microbial and Molecular Pathogenesis, Texas A&M University System Health Science Center, 77843-1114 College Station, Texas, USA;(3) Aeras Global TB Vaccine Foundation, 1405 Research Boulevard, 20850 Rockville, MD, USA |
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| Abstract: | Background Mouse virulence assessments of certain Mycobacterium tuberculosis mutants have revealed an immunopathology defect in which high tissue CFU counts are observed but the tissue pathology and
lethality are reduced. M. tuberculosis mutants which grow and persist in the mouse lungs, but have attenuated disease progression, have the immunopathology (imp) phenotype. The antigenic properties of these strains may alter the progression of disease due to a reduction in host immune
cell recruitment to the lungs resulting in disease attenuation and prolonged host survival. |
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