An intragenic distribution bias of DNA uptake sequences in <Emphasis Type="Italic">Pasteurellaceae</Emphasis> and <Emphasis Type="Italic">Neisseriae</Emphasis> |
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Authors: | Mark WJ van Passel |
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Institution: | (1) Laboratory of Microbiology, Wageningen University, Dreijenplein 10, 6703 HB Wageningen, The Netherlands |
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Abstract: | Most sequenced strains from Pasteurellaceae and Neisseriae contain hundreds to thousands of uptake sequence (US) motifs in their genome, which are associated with natural competence
for DNA uptake. The mechanism of their recognition is still unclear, and I searched for intragenic location patterns of these
motifs for clues about their distribution. In all cases, one orientation of the US has a higher occurrence in the reading
frame, and in all Pasteurellaceae, the US and the reverse complement motifs are biased towards the gene termini. These findings could help design experimental
set-ups to study preferential DNA uptake, thereby further unravelling the phenomenon of natural competence. |
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