Ancora: a web resource for exploring highly conserved noncoding elements and their association with developmental regulatory genes |
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| Authors: | Pär G Engström David Fredman Boris Lenhard |
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| Affiliation: | 1.Computational Biology Unit, Bergen Center for Computational Science, University of Bergen, Thormøhlensgate, N-5008 Bergen, Norway;2.Sars Centre for Marine Molecular Biology, University of Bergen, N-5008 Bergen, Norway;3.Programme for Genomics and Bioinformatics, Department of Cell and Molecular Biology, Karolinska Institutet, S-17177 Stockholm, Sweden |
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| Abstract: | Metazoan genomes contain arrays of highly conserved noncoding elements (HCNEs) that span developmental regulatory genes and define regulatory domains. We describe Ancora , a web resource that provides data and tools for exploring genomic organization of HCNEs for multiple genomes. Ancora includes a genome browser that shows HCNE locations and features novel HCNE density plots as a powerful tool to discover developmental regulatory genes and distinguish their regulatory elements and domains. |
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