Serum antioxidant enzyme activity in Parkinson's disease |
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| Authors: | Jawahar Kalra Ali H Rajput Subrahmanyam V Mantha Kailash Prasad |
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| Institution: | (1) Department of Pathology College of Medicine, University of Saskatchewan, S7N OXO Saskatoon, Saskatchewan, Canada;(2) Department of Medicine and Physiology, College of Medicine, University of Saskatchewan, S7N OXO Saskatoon, Saskatchewan, Canada;(3) Royal University Hospital, S7N OXO Saskatoon, Saskatchewan, Canada |
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| Abstract: | Summary The activities of superoxide dismutase (SOD; EC 1.15.1.1) and glutathione peroxidase (GSHPx; EC 1.11.1.9.), the enzymes that metabolize the superoxide anion and hydrogen peroxide, respectively, were measured in serum
from healthy subjects and patients with Parkinson's disease (PD). The activities of SOD and GSHPx in patients with PD were higher than those in normal healthy individuals. These results suggest that the increased activities
of these enzymes could be due to oxidative stress in the initial stages of this disease. |
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| Keywords: | oxidative stress Parkinson's disease superoxide dismutase glutathione peroxidase |
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