Synthesis and immunosuppressive activity evaluation of substituted N-imidazolidin-2-ones and N-tetrahydropyrimidin-2(1H)-ones |
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Authors: | Caroline Sabourin Jean-Michel Robert |
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Institution: | 1. Département de PharmacochimieFaculté de Pharmacie, Université de Nantes, Universités de Nantes AtlantiqueBioCiT UPRES EA 1155, 1 rue Gaston VeilF-44035NantesFrancecaroline.sabourin@univ-nantes.fr;3. Département de PharmacochimieFaculté de Pharmacie, Université de Nantes, Universités de Nantes AtlantiqueBioCiT UPRES EA 1155, 1 rue Gaston VeilF-44035NantesFrance |
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Abstract: | Seventeen compounds with either an imidazolin-2-one or a tetrahydropyrimidin-2(1H)-one scaffold were synthesized and evaluated for their immunosuppressive activity in a concanavallin A (ConA)-stimulated mouse splenocytes proliferation test. Three of these molecules exerted a significant activity at 90 μM. All the compounds of the tetrahydropyrimidin-2(1H)-one series have turned out to be inactive showing the crucial role of the imidazolidin-2-one scaffold in the induction of an immunosuppressive activity. |
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Keywords: | Imidazolidin-2-one tetrahydropyrimidin-2(1H)-one urea immunosuppressant agent |
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