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New N4-substituted piperazine naphthamide derivatives as BACE-1 inhibitors |
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| Authors: | Y Laras C Garino J Dessolin C Weck V Moret A Rolland |
| Institution: | 1. Laboratoire de Chimie Biomoléculaire, Faculté des Sciences Luminy, IBDML-UMR-6216-CNRS, Université de la Méditerranée, Marseille Cedex, France;2. Laboratoire de Chimie Bioorganique, UMR 7175-LC1 CNRS, Faculté de Pharmacie, Université Louis Pasteur, BP 60024, 67401 Illkirch Cedex, France;3. Université Bordeaux 1-ENITAB, Institut Européen de Chimie et Biologie (IECB), 2 rue Robert Escarpit, 33607 Pessac Cedex, France |
| Abstract: | Synthesis and enzymatic evaluation of new series of N4-substituted piperazine naphthamide derivatives as BACE-1 inhibitors for the treatment of Alzheimer's disease are reported. |
| Keywords: | Alzheimer's disease BACE-1 N4-substituted piperazine naphthamide |