Anti-inflammatory,analgesic and antipyretic activities of Physalis minima Linn |
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| Authors: | Murad Ali Khan Haroon Khan Sarwar Khan Tahira Mahmood Pir Mohammad Khan Abdul Jabar |
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| Institution: | 1. drmalikhan@yahoo.com;3. Gandhara College of Pharmacy, Gandhara University, Peshawar, N.W.F.P, Pakistan;4. Department of Chemistry, Jehanzeb Postgraduate College, Swat, Pakistan;5. Pakistan Council of Scientific and Industrial Research Laboratories Complex, Jamrud RoadPeshawar, Pakistan;6. Department of Chemistry, Islamia University, Bahawalpur, Pakistan |
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| Abstract: | In our present investigation, the crude methanol extract and chloroform fraction of the whole plant of Physalis minima Linn (Solanaceae) was investigated for anti-inflammatory, analgesic and antipyretic activities in NMRI mice and Wistar rats of either sex at 200 and 400 mg/kg, respectively. Various established in-vivo model's were used during the study. Both crude extract and chloroform fraction showed marked anti-inflammatory and analgesic activities as compared to a control at tested doses. The antipyretic potential of the crude extract and chloroform were insignificant in the Brewer's yeast fever model. Therefore, the whole plant of Physalis minima Linn could be considered as a potential candidate for bioactivity-guided isolation of natural anti-inflammatory and analgesic agents. |
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| Keywords: | Physalis minima anti-inflammatory analgesic antipyretic |
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