Synthesis and Evaluation of Disubstituted N1- and N3-Imidazolidin-2-ones Acting as Potential Immunosuppressive Agents |
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| Authors: | Caroline Sabourin Sylvie Robert-Piessard Delphine Carbonnelle Francois Lang |
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| Affiliation: | 1. Laboratoire de Pharmacochimie, UPRES EA 1155, Faculté de Pharmacie, 1 rue Gaston Veil, F-44035, Nantes, France;2. Laboratoire de Pharmacologie, UPRES EA 1155, Faculté de Pharmacie, 1 rue Gaston Veil, F-44035, Nantes, France |
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| Abstract: | New N1-mono and N1, N2-disubstituted imidazolidin-2-one with a significant immunosuppressive activity have been discovered. Among the 17 synthesized and tested compounds, five of them showed maximal inhibition of proliferation of concanavallin A (Con A)- stimulated splenocytes at 90?μM, identical to that obtained with cyclosporin A (CsA) at 5?μM, an optimal concentration. |
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| Keywords: | Ureas Imidazolidin-2-ones Immunosuppressive drugs |
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