Synthesis of a novel class of some 1,3,4-oxadiazole derivatives as antimicrobial agents |
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Authors: | Kishor H Chikhalia Dhaval B Vashi |
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Institution: | 1. Department of chemistry, School of Science, Gujarat University, Ahmedabad, 380 009, Gujarat, India;2. Department of chemistry, Veer Narmad South Gujarat University, Surat, 395 007, Gujarat, India |
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Abstract: | In an effort to discover new candidates with improved antimicrobial activities we report here the synthesis and in vitro biological evaluation of various series of 2-{(3,4,5-trimethoxy phenyl-1,3,4-oxadiazolyl)-5-thio}-4-(morpholino)-6-(phenyl ureido)-s-triazine (7a-i) and 2-{(3,4,5-trimethoxy phenyl-1,3,4-oxadiazolyl)-5-thio}-4-(morpholino)-6-(phenyl thioureido)-s-triazine (8a-g). Antimicrobial properties of the title compounds were investigated against two Gram ( + ve) bacteria (S. aureus, B. subtilis), two Gram ( ? ve) bacteria (P. aeruginosa, E. coli) and yeast-like fungi (C. albicans) using the broth microdilution method. |
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Keywords: | 1 3 4-oxadiazole s-triazine thiourea urea antimicrobial activity |
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