Synthesis and antioxidant evaluation of novel silybin analogues |
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| Authors: | Leixiang Yang Jingxu Gong Feng Wang Yongmin Zhang Yanguang Wang Xiaojiang Hao |
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| Affiliation: | 1. Department of Traditional Chinese Medicine and Natural Drug Research, College of Pharmaceutical Sciences, Zhejiang University, 353 Yan an Road, Hangzhou, 310031, P.R. China;2. ZJU-ENS Joint Laboratory of Medicinal Chemistry, Zhejiang University, Hangzhou, 310031, P.R. China;3. Department of Chemistry, College of Sciences, Zhejiang University, Hangzhou, 310027, P.R. China;4. The Key Laboratory of Chemistry of Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang, 550022, P.R. China |
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| Abstract: | In this work, we evaluated the antioxidant properties of the eight novel silybin analogues for their capacity to scavenge free radicals including superoxide anion radicals and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals in vitro. Compound 7d demonstrated an excellent antioxidant effect in scavenging superoxide anion free radical with an IC50 value of 26.5 μM, while the IC50 of quercetin (the reference compound) was 38.1 μM. Compounds 7b, 7e, 7h showed certain scavenging activities for both types of free radicals. |
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| Keywords: | Antioxidant superoxide anion DPPH silybin analogues free radical scavenging |
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