Synthesis and PreliminaryIn Vitro Evaluation of Antimycobacterial Activity of New Pyrrolo[1,2-a]quinoxaline-carboxylic Acid Hydrazide Derivatives |
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| Authors: | Jean Guillon Robert C. Reynolds Jean-Michel Leger Marie-Aude Guie Stephane Massip Patrick Dallemagne |
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| Affiliation: | 1. EA- Pharmacochimie, UFR des Sciences Pharmaceutiques, Université Victor Segalen Bordeaux 2, 146 rue Léo Saignat, 33076, Bordeaux Cedex, France;2. National Institute of Allergy and Infectious Diseases - TAACF, Southern Research Institute, 2000 Ninth Avenue South, Birmingham, AL, 35255, USA;3. Centre d'Etudes et de Recherche sur le Médicament de Normandie, UFR des Sciences Pharmaceutiques, 1 rue Vaubénard, 14032, Caen Cedex, France |
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| Abstract: | New pyrrolo[1,2-a]quinoxaline-2- or -4-carboxylic acid hydrazide derivatives were synthesized from nitroaniline or 1,2-phenylenediamine, and evaluated in vitro for their antimycobacterial activity as part of a TAACF TB screening program. Two compounds 7c and 13 showed an interesting activity at 6.25?μg/mL against Mycobacterium tuberculosis H37Rv, with a 94 and 100 percentage inhibition, respectively. |
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| Keywords: | Pyrrolo[1,2-a]quinoxaline-carboxylic acid hydrazide derivatives Mycobacterium tuberculosis Antimycobacterial agents Tuberculosis |
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