Synthesis and preliminary antiproliferative evaluation of 1,3,9-triazacyclopenta[b]fluorene derivatives |
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| Authors: | Gwenaelle Desforges Laurent Picot Cyril Montagne Valérie Thiéry Thierry Besson Benoit Joseph |
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| Affiliation: | 1. Laboratoire de Chimie Organique 1, UMR-CNRS 5181, Université Claude Bernard – Lyon 1, CPE – Batiment 308, 43 Boulevard du 11 Novembre 1918, 69622, Villeurbanne cedex, France;2. Laboratoire de Biotechnologies et Chimie Bio-organique, FRE-CNRS 2766, UFR Sciences Fondamentales et Sciences pour l'Ingénieur, Batiment Marie Curie, Université de la Rochelle, F-17042, La Rochelle cedex 1, France |
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| Abstract: | Novel 1,3,9-triazacyclopenta[b]fluorene-4,10-diones and 1,3,9-triazacyclopenta[b]fluorene, analogue of ellipticine, were synthesised, and evaluated in vitro for their antiproliferative activity on various breast cancer cell lines. |
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| Keywords: | 1,3,9-Triazacyclopenta[b]fluorene bioisostere antiproliferative activity breast cancer cell lines ellipticine |
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