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Synthesis and PC3 androgen-independent prostate cells antiproliferative effect of fagaronine derivatives |
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| Authors: | Enguerran Vanquelef Jean-Jacques Hélesbeux Olivier Duval Eric Debiton Chantal Barthomeuf Christian Jarry |
| Affiliation: | 1. Univ Angers, SONAS, UFR Sciences Pharmaceutiques et Ingénierie de la Santé, Angers, F-49100, France;2. Centre Jean Perrin, Clermont-Ferrand, F-63005, France, 63005, France, Clermont-Ferrand, 63005, France;3. Univ Bordeaux 2, U.F.R. Pharmacie, EA 2962 Pharmacochimie, Bordeaux, F -33076, France |
| Abstract: | Fagaronine derivatives syntheses were optimized and their effect on PC3 androgen-independent prostate cell line was evaluated. An assessment of the lipophilicity of the benzo[c]phenanthridine derivatives was achieved at pH 7.4 and et 6.7 by determining log D. |
| Keywords: | Fagaronine benzo[c]phenanthridine PC3 androgen-independent cell line log D |