Selective Inhibition of Acetylcholinesterase in the Cerebellum and Hippocampus of Mice Following an Acute Treatment with Malathion |
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| Authors: | Marek Banasik † Todd Stedeford † Amanda S. Persad Kunihiro Ueda Seigo Tanaka Carlos Muro-Cacho |
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| Affiliation: | 1. Laboratory of Toxicology and Risk Assessment, Institute of Coal Chemistry, Polish Academy of Sciences, 44-121, Gliwice, Poland;2. Center for Environmental and Occupational Risk Analysis and Management, Department of Environmental and Occupational Health, College of Public Health, University of South Florida, Florida, 33612, Tampa, USA;3. Laboratory of Molecular Clinical Chemistry, Institute for Chemical Research, Kyoto University, Uji, 611-0011, Kyoto, Japan;4. Department of Interdisciplinary Oncology, H. Lee Moffitt Cancer Center and Research Institute, Florida, 33612, Tampa, USA |
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| Abstract: | Adult male ICR mice were treated by intraperitoneal injection with 250?mg/kg of bodyweight of commercial malathion (a dose corresponding to 1/12 the LD50). After 6?h, acetylcholinesterase (AChE) activity in blood, liver, and six brain regions was determined. A statistically significant inhibition was observed in whole blood (23%), liver (21%), and, in particular, the central nervous system; the greatest degree of AChE inhibition was observed in the cerebellum (45%), followed by the hippocampus (29%). There was no significant change in AChE activity in the caudate putamen, frontal cortex, midbrain, or pons medulla. These results demonstrate that the magnitude of AChE inhibition in peripheral tissues does not accurately reflect the central-inhibitory effects of malathion on AChE activity in specific brain regions. |
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| Keywords: | Malaoxon Mouse brain regions Organophosphate pesticides Peripheral markers |
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