Synthesis,antifungal and antioxidant screening of some novel benzimidazole derivatives |
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| Authors: | Ilgar Kerimov Gülgün Ayhan-Kilcigil Benay Can-Eke Nurten Altanlar Mümtaz İscan |
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| Affiliation: | 1. Department of Pharmaceutical Chemistry Faculty of Pharmacy, Ankara University, 06100 Tandogan, Ankara, Turkey;2. Department of Toxicology Faculty of Pharmacy, Ankara University, 06100 Tandogan, Ankara, Turkey;3. Department of Pharmaceutical Microbiology Faculty of Pharmacy, Ankara University, 06100 Tandogan, Ankara, Turkey |
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| Abstract: | Some novel benzimidazole derivatives were synthesized and their in vitro effects on rat liver microsomal NADPH-dependent lipid peroxidation (LP) level, ethoxyresorufin O-deethylase (EROD) and antifungal activities were determined. A significant decrease in male rat liver microsomal LP level was noted by compounds 4c (52%), 4e (58%) and 4h (43%) at 10? 3 M concentration. Compounds 4c (100.0%), 4h (100.0%), 5c (98.0%) and 5h (100.0%) inhibited the microsomal ethoxyresorufin O-deethylase (EROD) enzyme activity better than that of the specific inhibitor caffeine (85%). Among these compounds, only compounds 4b and 4h exhibited moderate activity against C.albicans whereas the others had weak effects. |
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| Keywords: | Thiosemicarbazides thiadiazolylmethylbenzimidazoles triazolylmethylbenzimidazoles antimicrobial activity antioxidant activity lipid peroxidation |
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