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Synthesis and Antiviral Effect against Herpes Simplex Type 1 of 12-substituted Benzo[c]phenanthridinium Salts |
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| Authors: | Enguerran Vanquelef Maryvonne Amoros Joel Boustie Michael A Lynch Roger D Waigh |
| Institution: | 1. Laboratoire SONAS, UFR des Sciences Pharmaceutiques et Ingénierie de la Santé, 16,Bd Daviers, 49100, Angers, France;2. Faculté de Pharmacie, Laboratoire de pharmacognosie et mycologie, 2. av Prof Léon Bernard Rennes cedex, 35043, France;3. Department of Pharmaceutical Sciences, Strathclyde Institute for Biomedical Sciences, 27 Taylor Street G4 ONR, Scotland, Glasgow, UK |
| Abstract: | The synthesis of benzoc]phenanthridine alkaloid derivatives is described. In vitro antiviral activity against herpes simplex type 1 (HSV1) has been investigated. Contrary to the natural product fagaronine, which did not have any activity in the HSV1 antiviral tests, four 12-alkoxy derivatives showed good activity demonstrating the importance of the 12-substitution in the structure-activity relationships. |
| Keywords: | Benzo[c]phenanthridines Fagaronine 12-alkoxy derivatives Antiviral activity HSV1 |