Anti-leukemia Activity of 7-hydroxy-2-substituted-methyl-5 H -oxazolo[3,2- a] pyrimidin-5-one Derivatives |
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| Authors: | Jean Guillon Maria Mamani-Matsuda Stephane Massip Jean-Michel Leger Denis Thiolat Djavad Mossalayi |
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| Affiliation: | 1. EA 2962--Pharmacochimie, Université Victor Segalen Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux cedex, France;2. Laboratoire d'Immunologie et Parasitologie, CNRS UMR 5540, Université Victor Segalen Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux cedex, France |
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| Abstract: | The synthesis of new 7-hydroxy-2-substituted-methyl-5 H -oxazolo3,2- a] pyrimidin-5-ones derivatives, designed as structural bicyclic analogues of the iron chelator deferiprone, is described. They were tested for their ability to inhibit proliferation in human Bcr-Abl + leukemia cells. |
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| Keywords: | Anti-leukemia Iron Chelator Oxazolo[3 2- a] pyrimidin-5-one |
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