Synthesis and antimycobacterial activity of 4-[5-(substituted phenyl)-4, 5-dihydro-3-isoxazolyl]-2-methylphenols |
| |
| Authors: | Mohammad Shaharyar Mohamed Ashraf Ali Mohammad Afroz Bakht Vel Murugan |
| |
| Institution: | 1. Faculty of Pharmacy, Jamia Hamdard University, Department of Pharmaceutical Chemistry, Hamdard Nagar, New Delhi, 110062, India;2. Alwar Pharmacy College, Department of Medicinal Chemistry, Alwar-Rajasthan, 301030, India |
| |
| Abstract: | Compounds based on the isoxazoline moiety were screened for their antimycobacterial activity in vitro against Mycobacterium tuberculosis H37R (MTB), and INH (isoniazid) resistant Mycobacterium tuberculosis (INHR-MTB) using the agar dilution method and bactec 460. Among the synthesized compounds, 4-5-(4-bromophenyl)-4,5-dihydro-3-isoxazolyl]-2-methylphenol (4l) was found to be the most active agent against MTB and INHR-MTB with minimum inhibitory concentration of 0.62 μM. When compared to INH, compound (4l) was 1.12 fold and 3.0 fold more active against MTB and INHR-MTB, respectively. |
| |
| Keywords: | Isoxazolyl antimycobacterial agent Mycobacterium tuberculosis |
|
|
