Calpain inhibitory flavonoids isolated from Orostachys japonicus |
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| Authors: | Choong Je Ma Won Joo Jung Ki Yong Lee Young Choong Kim |
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| Affiliation: | College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul, 151-742, Republic of Korea |
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| Abstract: | The n-butanol (n-BuOH) fraction of Orostachys japonicus A. Berger (Crassulaceae) significantly inhibited calpain activity. Through the activity-guided isolation from the n-BuOH fraction, herbacetin 8-O-α-D-ribopyranoside (1), kaempferol (2), quercetin (3), afzelin (4), astragalin (5), isoquercetin (6) and quercitrin (7) were obtained. Their structures were determined by spectroscopic techniques. Among them, compound 3 and 5 had significant calpain inhibitory activities. |
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| Keywords: | Orostachys japonicus flavonoid calpain neuroprotection inhibition |
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