Synthesis,antioxidant and radical scavenging activities of novel benzimidazoles |
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| Authors: | Gülgün Ayhan-KIlcig?l Canan Ku? Tülay Çoban Benay Can-Eke Süheyla Özbey Mümtaz Iscan |
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| Institution: | 1. Department of Pharmaceutical Chemistry and;2. Ankara University, Department of Toxicology, Faculty of Pharmacy, 06100, Tando?an, Turkey;3. Hacettepe University, Department of Engineering Physics, Faculty of Engineering, 06800, Beytepe, Ankara, Turkey |
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| Abstract: | The synthesis and antioxidant evaluation of some novel benzimidazole derivatives (10–24) are described. Antioxidant properties of the compounds were investigated employing various in vitro systems viz., microsomal NADPH-dependent inhibition of lipid peroxidation (LP), interaction of 2,2-diphenyl-1-picrylhydrazyl (DPPH) and scavenging of superoxide anion radical. Compounds 12 and 13 showed very good antioxidant capacity and were 17–18 -fold more potent than BHT (IC50 2.3 × 10? 4M) with 1.3 × 10? 5M and 1.2 × 10? 5M IC50 values, respectively, by interaction of the stable DPPH free radical. |
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| Keywords: | Thiosemicarbazides thiadiazolylmethylbenzimidazoles triazolylmethylbenzimidazoles antioxidant activity X-ray structure analysis radical scavenging |
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